On the Hawaiian island of Molokaʻi lies Kalaupapa, a remote natural prison that was once the world’s most notorious leprosy colony. From this place of exile emerged two Catholic saints and a legacy of radical compassion. With only two Hansen’s disease patients remaining, two Sisters of St. Francis now carry out the final chapter of a 150-year ministry, serving with quiet dignity until the last patient dies. Filmed over the last fifteen years, Of Saints and Exiles captures the end of a living community shaped by suffering, faith, and grace.